Bayesian Progress Curve Analysis of MicroScale Thermophoresis Data

Aptamer Binding Studies Using MicroScale Thermophoresis.

The characterization and development of highly specific aptamers requires the analysis of the interaction strength between aptamer and target. MicroScale Thermophoresis (MST) is a rapid and precise method to quantify biomolecular interactions in solution at microliter scale. The basis of this technology is a physical effect referred to as thermophoresis, which describes the directed movement of...

Studying epigenetic interactions using MicroScale Thermophoresis (MST)

Epigenetic regulation is based on specific molecular interactions between epigenetic reader, writer and eraser molecules and chromatin. Binding parameters of these interactions such as binding affinities, stoichiometries and thermodynamics are essential for the understanding of the establishment and maintenance of epigenetic networks. The MicroScale Thermophoresis (MST) is a rapid and precise m...

Molecular interaction studies using microscale thermophoresis.

Abstract The use of infrared laser sources for creation of localized temperature fields has opened new possibilities for basic research and drug discovery. A recently developed technology, Microscale Thermophoresis (MST), uses this temperature field to perform biomolecular interaction studies. Thermophoresis, the motion of molecules in temperature fields, is very sensitive to changes in size, c...

Bayesian Prediction in Spatial Data Analysis

Bayesian Catch Curve Analysis

Catch curves have been used to estimate survival and instantaneous mortality for fish and wildlife populations for many years. In order to better analyze catch curve data from the Apostle Islands population lake trout Salvelinus namaycush in Lake Superior, we develop a Bayesian approach to catch curve analysis. First, the proposed Bayesian approach is illustrated for a single catch curve and th...